compound introduction
DRP1i27 is a potent inhibitor of human Drp1 (dynamin-related protein 1). DRP1i27 binds to the GTPase site of Drp1, with hydrogen bonds to Gln34 and Asp218. DRP1i27 targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia-reperfusion injury. In Vitro DRP1i27 (0-50 µM) directly binds to and inhibits GTPase activity of human Drp1. DRP1i27 (0-50 µM) is able to increase cellular networks of mitochondria in human and mouse fibroblasts in a Drp1-dependent manner. DRP1i27 has a binding affinity of 286 µM in the SPR assay and a K D value of 190 µM via the MST assay. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
