ATN-161 trifluoroacetate salt is a novel integrin α5β1 antagonist, which inhibits angiogenesis and growth of liver metastases in a murine model. In Vitro The combination of ATN-161 plus 5-FU significantly reduces tumor cell proliferation compared to control and single-agent therapy (p In Vivo The preliminary experiments with α5β1-negative human colon cancer xenografts (HT29) show that treatment with ATN-161 significantly reduces tumor weight and vessel density . Injection of ATN-161 after laser photocoagulation inhibits choroidal neovascularization (CNV) leakage and neovascularization to an extent similar to AF564. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Integrin α5β1
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
ATN-161 trifluoroacetate salt
CAS number：904763-27-5 molecular formula：C25H36F3N9O10S
overview
compound introduction
Specs
| Chinese alias | ATN-161 三氟乙酸盐 | ||
| English alias | - | ||
| CAS number | 904763-27-5 | molecular formula | C25H36F3N9O10S |
| molecular weight | 711.67 g/mol | Exact mass | ≥95% |
| PSA | 310.000 Ų | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
