Cyclo(Arg-Gly-Asp-D-Phe-Cys) (Cyclo RGDfC) TFA, a cyclic RGD peptide which has high affinity to αvβ3 , can disrupt cell integrin interactions. Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA inhibits pluripotent marker expression in embryonic stem cells (ESCs) and the t Appearance:Solid IC50& Target:αvβ3 In Vitro:Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA (0.5 mM; 24 h) down-regulates the transcription factors Oct 4, Sox 2 and Nanog of mESCs. Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA (0.5 mM) inhibits integrin gene expression mESC-col I (type I collagen) constructs. Cyclo( In Vivo:Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA (0.5 mM, 24 h)-treated mESCs in the presence/absence of Leukemia inhibitory factor (LIF) (injected in both thighs) generated teratomas in severe combined immunodeficiency (SCID) mice, which indicates that the process of mE Biological Activity:Cyclo(Arg-Gly-Asp-D-Phe-Cys) (Cyclo RGDfC) TFA, a cyclic RGD peptide which has high affinity to αvβ3 , can disrupt cell integrin interactions. Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA inhibits pluripotent marker expression in embryonic stem cells (ESCs) and the t
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Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA
CAS number：unknown molecular formula：C26H35F3N8O9S
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| Chinese alias | 环(精氨酸-甘氨酸-天冬氨酸-D-苯丙氨酸-半胱氨酸)三氟乙酸 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C26H35F3N8O9S |
| molecular weight | 692.66 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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