JB061 is a nonmuscle myosin inhibitor with IC 50 s of 4.4 μM ( Cardiac muscle myosin ), 9.1 μM ( Skeletal muscle myosin ), and >100 μM ( Smooth muscle myosin II ), respectively. JB061 poorly decreases ATPase activity ( IC 50 >200 μM). JB061 shows cytotoxi IC50& Target:Cardiac muscle myosin 4.4 μM (IC 50 ) Skeletal muscle myosin 9.1 μM (IC 50 ) Smooth muscle myosin II >100 μM (IC 50 ) In Vitro:JB061 (compound 6a) (40 μM; 24 h) inhibits cytokinesis in Cos-7 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Biological Activity:JB061 is a nonmuscle myosin inhibitor with IC 50 s of 4.4 μM ( Cardiac muscle myosin ), 9.1 μM ( Skeletal muscle myosin ), and >100 μM ( Smooth muscle myosin II ), respectively. JB061 poorly decreases ATPase activity ( IC 50 >200 μM). JB061 shows cytotoxi
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JB061
CAS number：unknown molecular formula：C19H17NO4
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C19H17NO4 |
| molecular weight | 323.34 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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