EG01377 dihydrochloride is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1) , with a K d of 1.32 μM, and IC 50 s of 609 nM for both NRP1-a1 and NRP1-b1 . EG01377 dihydrochloride has antiangiogenic, antimigratory, and antitumor effects IC50& Target:IC50: 609 nM (NRP1-a1 and NRP1-b) In Vitro:EG01377 (3-30 μM; 30 minutes) inhibits vascular endothelial growth factor A (VEGF-A) stimulated tyrosine phosphorylation of VEGF-R2/KDR. EG01377 (30 μM) is able to significantly reduce HUVEC cell migration in response to VEGFA. EG01377 (30 μM; 5 In Vivo:EG01377 (2mg/kg; i.v.) exhibits an encouraging half-life of 4.29 h, sufficient to sustain once per day dosing in mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 6-8 week-old BABL/c Biological Activity:EG01377 dihydrochloride is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1) , with a K d of 1.32 μM, and IC 50 s of 609 nM for both NRP1-a1 and NRP1-b1 . EG01377 dihydrochloride has antiangiogenic, antimigratory, and antitumor effects
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EG01377 dihydrochloride
CAS number：unknown molecular formula：C26H32Cl2N6O6S2
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| Chinese alias | EG01377 二盐酸盐 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C26H32Cl2N6O6S2 |
| molecular weight | 659.6 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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