PMX 205 Trifluoroacetate is a potent complement C5a receptor ( C5aR ; CD88 ) antagonist. Appearance:Solid IC50& Target:C5aR In Vitro:A complement activation product, C5a, is known to recruit and activate microglia and astrocytes in vitro by activation of a G protein-coupled cell-surface C5aR. In the MTT assay, in 24 h plate, it shows that all groups are significant when compared with n In Vivo:PMX 205 (PMX205) is an orally active, selective C5aR antagonist. Animals treated with PMX 205 (1mg/kg/day, oral) display a significant extension of survival time and a reduction in end-stage motor scores, as compared with vehicle-treated rats. PMX 205-tr Biological Activity:PMX 205 Trifluoroacetate is a potent complement C5a receptor ( C5aR ; CD88 ) antagonist.
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
PMX 205 Trifluoroacetate
CAS number：unknown molecular formula：C47H63F3N10O8
overview
compound introduction
Specs
| Chinese alias | PMX 205 三氟乙酸盐 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C47H63F3N10O8 |
| molecular weight | 953.06 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
