Veledimex S enantiomer (INXN-1001 S enantiomer) is the S enantiomer of veledimex. Veledimex is an oral activator ligand for a proprietary gene therapy promoter system, and a moderate inhibitor of and substrate for CYP3A4/5 In Vivo Veledimex generally has moderate to low oral bioavailability after a single oral administration in mice and monkeys (-56% in mice and up to 17.4% in cynomolgus monkeys) with mostly low plasma clearance (1399 and 1170 mL/h per kilogram in mice and monkeys, respectively), high volume of distribution (20271 and 9180 mL/h per kilogram in mice and monkeys, respectively), and long terminal half-lives (-10 hours in mice and -30 hours in monkeys) after intravenous administration . Ad-RTS-mIL-12 + veledimex have demonstrated a dose-related increase in tumor IL-12 mRNA and IL-12 protein expression. Discontinuation of veledimex resulted in a return to baseline IL-12 mRNA and protein expression in numerous syngeneic mouse tumor models. Veledimex crosses the blood-brain-barrier in both naive and orthotopic GL-261 mice with increased brain tissue level of -6 fold observed in tumor bearing vs. normal mice. Ad-RTS-mIL-12 + veledimex demonstrate a dose-related increase in survival without significant adverse events. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IL-1
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Veledimex (S enantiomer)
CAS number：1093131-03-3 molecular formula：C27H38N2O3
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| Chinese alias | Veledimex（S 对映体） | ||
| English alias | N'-(3,5-dimethylbenzoyl)-N'-[(3S)-2,2-dimethylhexan-3-yl]-2-ethyl-3-methoxybenzohydrazide | SCHEMBL2681772 | Veledimex (S enantiomer) | INXN-1001 S enantiome | RG-115932 S enantiome | HY-16785B | Veledimex(Senantiomer) | 2-Ethyl-3-methoxybenzoic acid 2-(3 | ||
| CAS number | 1093131-03-3 | molecular formula | C27H38N2O3 |
| molecular weight | 438.60 g/mol | Exact mass | ≥99% |
| PSA | 58.600 Ų | logp | 7.1 |
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