KR-33493 is a potent inhibitor of Fas-mediated cell death ( FAF1 ). In Vivo Body weight changes of both sexes are not related to KR-33493 in all doses. In rats administrated KR-33493 for 4 weeks, no test article-related changes in any treated groups of either sex are found in hematology, serum biochemistry, and urinalysis. In dogs administrated KR-33493 for 2 weeks, red blood cell count (RBC) value in males is significantly higher at the 1000 mg/kg/day dose than that of the control group (i.e., 6.96±0.323 vs. 6.12±0.418). However, the change of RBC is recovered after the end of the administration period. The dose-normalized AUC last is not significantly different between the groups, suggesting that KR-33493 is governed by linear kinetics . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Fas
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KR-33493
CAS number：1021497-97-1 molecular formula：C20H18BrN3O3S
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| Chinese alias | - | ||
| English alias | UNII-NCH0QD81ZR | SCHEMBL1875570 | AKOS032960445 | F85518 | HY-100755 | AC-35452 | KR-33494 | KR-33493 | 1021497-97-1 | 4-(2-(4-Bromophenylthio)acetamido)-1-phenethyl-1H-pyrazole-3-carboxylic acid | EX-A1269 | KM-819 | NCH0QD81ZR | 4-[2-(4-bromo-phenylsul | ||
| CAS number | 1021497-97-1 | molecular formula | C20H18BrN3O3S |
| molecular weight | 460.34 g/mol | Exact mass | ≥99% |
| PSA | 110.000 Ų | logp | 4.600 |
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