DCVC (S-[(1E)-1,2-dichloroethenyl]--L-cysteine) is a bioactive metabolite of trichloroethylene (TCE). DCVC inhibits pathogen-stimulated pro-inflammatory cytokines IL-1β, IL-8 , and TNF-α release from tissue cultures. In Vitro Extraplacental membranes are cultured for 4, 8, and 24h with the trichloroethylene (TCE) metabolite S-(1,2-dichlorovinyl)-l-cysteine (DCVC) in the absence or presence of lipoteichoic acid (LTA) or lipopolysaccharide (LPS) to simulate infection. In addition, membranes were cocultured with DCVC and Group B Streptococcus (GBS). DCVC (5-50μM) significantly inhibited LTA-, LPS-, and GBS-stimulated cytokine release from tissue cultures as early as 4h. DCVC inhibits pathogen-stimulated cytokine (IL-1β, IL-8, and TNF-α) release in a concentration-dependent manner. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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DCVC
CAS number：13419-46-0(DMSO) molecular formula：C5H7Cl2NO2S
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 13419-46-0(DMSO) | molecular formula | C5H7Cl2NO2S |
| molecular weight | 216.09 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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