HSD1590 is potent ROCK inhibitor, with IC 50 s of 1.22 and 0.51 nM for ROCK1 and ROCK2 , respectively. HSD1590 exhibits single digit nanomolar binding to ROCK (K d s In Vitro HSD1590 (0.5-1 µM; 24 hours) exhibits an impressive attenuation in migration. HSD1590 (0.5-10 µM; 12-24 horus) shows that the excellent migration inhibition observed is not due to cell death, but inhibition of live cell migration. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: MDA-MB-23 cells Concentration: 0.5-10 µM Incubation Time: 12-24 hours Result: Exhibited approximately 80% viability at 12 hours and yielded an overall viability of 63% at 24 h. Form:Solid IC50& Target:ROCK1 1.22 nM (IC 50 ) ROCK2 0.51 nM (IC 50 )
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
HSD1590
CAS number：2379279-96-4 molecular formula：C20H18BN3O3
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2379279-96-4 | molecular formula | C20H18BN3O3 |
| molecular weight | 359.19 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
