compound introduction
Hh-Ag1.5 (SAg1.5) is a potent Hedgehog ( Hh ) agonist with an EC 50 of 1 nM Hh-Ag1.5 mediated reprogramming breaks the quiescence of noninjured liver stem cells for rescuing liver failure . In Vitro HhAg1.5 (5 μM; for 3 weeks) facilitates dramatic expansion of quiescent CD133 + CD45 - liver stem cells (Hh3A cells) enriched from non-injured liver in vitro. Hh-Ag1.5 competely binds to the Smo-containing membranes with the K i value of 0.52 nM. The Smo agonist SAG-1.5 displays nanomolar-range potency stimulation of Gli-responsive reporter activity, with an EC 50 of 7 nM . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:EC50: 1 nM (Hedgehog)
