NSC-370284 is a selective inhibitor of ten-eleven translocation 1 ( TET1 ) and 5-hydroxymethylcytosine ( 5hmC ). NSC-370284 significantly inhibits the level of TET1 expression via targets STAT3/5 In Vitro NSC-370284 (0-500 nM; 24 h or 48 h) inhibits the viability of MONOMAC-6, THP-1, KOCL-48 and KASUMI-1 acute myeloid leukemia (AML) cells via targeting STAT3/5. NSC-370284 significantly down-regulates the level of TET1 transcription. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: AML cell lines including MONOMAC-6, THP-1, KOCL-48, and KASUMI-1. Concentration: 0, 25, 50, 200 or 500 nM. Incubation Time: 24 h or 48 h. Result: Showed inhibitory for AML cells viability and TET1 transcription. In Vivo NSC-370284 (2.5 mg/kg; i.p., once daily for 10 days) improves the pathological morphologies in peripheral blood (PB), bone marrow (BM), spleen, and liver tissues in MLL-AF9 acute myeloid leukemia (AML) mice model . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57BL/6 (CD45.2) and B6.SJL (CD45.1) mice . Dosage: 2.5 mg/kg. Administration: Intraperitoneal injection, once daily, for 10 days. Result: Significantly inhibited MLL-AF9 induced AML in secondary bone marrow transplantation (BMT) recipient mice. Form:Solid IC50& Target:STAT3 STAT5 TET1
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NSC-370284
CAS number：116409-29-1 molecular formula：C21H25NO6
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| Chinese alias | - | ||
| English alias | NCI60_003410 | AKOS024282084 | 6-[1-pyrrolidinyl-(3,4,5-trimethoxyphenyl)methyl]-1,3-benzodioxol-5-ol | 6-(1-Pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl)-1,3-benzodioxol-5-ol | 6-[(3,5-Trimethoxyphenyl)-1-pyrrolidinylmethyl]-1,3-benzodioxol-5-ol | {6-[(3,4 | ||
| CAS number | 116409-29-1 | molecular formula | C21H25NO6 |
| molecular weight | 387.43 g/mol | Exact mass | ≥96% |
| PSA | 69.600 Ų | logp | 3.3 |
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