Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC 50 of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation In Vitro Angoline (0-100 μM; 1 h) inhibits STAT3, STAT1 and NF-κB signaling pathways with IC 50 values of 11.56, ＞100 and ＞100 μM, respectively. Angoline (0-100 μM; 2 h) affects phosphorylation of STAT3. Angoline (0-100 μM; 72 h) inhibits MDA-MB-231, H4 and HepG2 cells proliferation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: HepG2/STAT3 cell line Concentration: 0, 1, 10, 30 and 100 μM Incubation Time: 2 hours Result: Inhibited IL-6-induced phosphorylation of STAT3 in HepG2/STAT3 cells. Cell Proliferation AssayCell Line: MDA-MB-231, H4 and HepG2 cell lines Concentration: 0-100 μM Incubation Time: 72 hours Result: Inhibited proliferation of MDA-MB-231, H4 and HepG2 cells with IC 50 values of 3.32, 4.72 and 3.14 μM, respectively. Form:Solid IC50& Target:IC50: 11.56 μM (IL6/STAT3 signaling pathway), 3.32 μM (MDA-MB-231), 4.72 μM (H4), 3.14 μM (HepG2)
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
Angoline
CAS number：21080-31-9 molecular formula：C22H21NO5
overview
compound introduction
Specs
| Chinese alias | 安哥林 | ||
| English alias | HY-N7674 | ( inverted exclamation markA)-Angoline | SureCN13103356 | DTXSID90943391 | AKOS040763668 | C09336 | SCHEMBL13103356 | AC1Q703U | CHEBI:2721 | 1,2,13-Trimethoxy-12-methyl-12,13-dihydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridine | 6-Methox | ||
| CAS number | 21080-31-9 | molecular formula | C22H21NO5 |
| molecular weight | 379.41 g/mol | Exact mass | ≥99% |
| PSA | 49.400 Ų | logp | 4.2 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
