KY-02327 acetate, a metabolically stabilized KY-02061 analog, is a potent Dishevelled (Dvl)-CXXC5 interaction inhibitor. KY-02327 acetate shows an activating effect on the Wnt/β-catenin pathway, resulting in promotion of osteoblast differentiation. Appearance:Solid In Vitro:KY-02327 (1-10 μM; 2 days; MC3T3E1 cells, a murine pre-osteoblast cell line) acetate increases β-catenin protein level together with Runx2 and accumulated nuclear β-catenin in a dose-dependent manner. KY-02327 (1-10 μM) acetate increases the mRNA lev In Vivo:KY-02327 (20mg/kg; p.o.; 5 sequential days per week for 4 weeks) acetate successfully rescues bone loss in the ovariectomized (OVX) mouse model. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Biological Activity:KY-02327 acetate, a metabolically stabilized KY-02061 analog, is a potent Dishevelled (Dvl)-CXXC5 interaction inhibitor. KY-02327 acetate shows an activating effect on the Wnt/β-catenin pathway, resulting in promotion of osteoblast differentiation.
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KY-02327 acetate
CAS number：unknown molecular formula：C22H31N3O6
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| Chinese alias | KY-02327 醋酸盐 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C22H31N3O6 |
| molecular weight | 433.5 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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