SNT207858 free base is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 ( MC-4 ) receptor antagonist. SNT207858 free base has an IC 50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor In Vitro SNT207858 binds to the MC-4 receptor with an affinity of 22 nM and shows a 170-fold selectivity vs. MC-3 and a 40-fold selectivity vs. MC-5. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo SNT207858 (30 mg/kg; oral administration; once daily; 15 days) significantly reduces the tumor induced weight loss in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Mice with C26 adenocarcinoma-induced cachexia model Dosage: 30 mg/kg Administration: Oral administration; once daily; 15 days Result: Significantly reduced the tumor induced weight loss. IC50& Target:MC-4 receptor
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SNT-207858 free base
CAS number：1104662-66-9(DMSO) molecular formula：C32H43Cl2N5O3
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| Chinese alias | SNT-207858 游离碱 | ||
| English alias | - | ||
| CAS number | 1104662-66-9(DMSO) | molecular formula | C32H43Cl2N5O3 |
| molecular weight | 616.62 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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