compound introduction
GLUT inhibitor-1 is a potent and orally active inhibitor of glucose transporters, targeting both GLUT1 and GLUT3 , with IC 50 s of 242 nM and 179 nM, respectively. GLUT inhibitor-1 has the potential for the reaesrch of cancers and autoimmune diseases In Vivo Summary of the pharmacokinetic parameters of GLUT inhibitor-1 (compound 15b; 30 mg/kg) in mouse and rat . Parameter Mouse Rat oral C max (ng/mL) 2525 1675 oral AUC (ng/mL) 5890 6813 CL (mL/min/kg) 40 37 V dss (L/Kg) 1.70 4.51 t 1/2 (h) 0.785 2.59 F (%) 45.4 49.4 B/P b 0.05 b: Solubility is determined in PBS buffer solutions. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:GLUT1 242 nM (IC 50 ) GLUT3 179 nM (IC 50 )
