15-LOX-1 inhibitor 1 is a potent inhibitor of 15-LOX-1 (15-lipoxygenase-1) with an IC 50 value of 0.19 μM. 15-LOX-1 inhibitor 1 protects macrophages from lipopolysaccharide-induced cytotoxicity. 15-LOX-1 inhibitor 1 inhibits NO formation and lipid peroxidation In Vitro 15-LOX-1 inhibitor 1 (Compound 9c) (0-5 μM; 24 hours) protects RAW 264.7 macrophages from LPS-induced cell death and shows stronger, dose-dependent effects with a 20% viability increase at 5 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: RAW 264.7 macrophages Concentration: 0, 0.2, 1, 5 μM 15-LOX-1 inhibitor 1 and lipopolysaccharides (LPS) (100 μg/mL) Incubation Time: 24 hours Result: Showed stronger, dose-dependent effects with a 20% viability increase at 5 μM. Form:Solid IC50& Target:15-LOX-1 0.19 μM (IC 50 )
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15-LOX-1 inhibitor 1
CAS number：2349374-37-2 molecular formula：C22H21ClN2O4
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| Chinese alias | 15-LOX-1 抑制剂 1 | ||
| English alias | - | ||
| CAS number | 2349374-37-2 | molecular formula | C22H21ClN2O4 |
| molecular weight | 412.87 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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