Z-VDVAD-FMK is a special inhibitor of caspase-2 . Z-VDVAD-FMK produces a reduction in Lovastatin-induced apoptosis In Vitro Cotreatment of cells with the caspase inhibitors Ac-DEVD-CHO, Z-VDVAD-FMK (100 μM), Z-IETD-fmk, and Z-LEHD-fmk alone or in combination, or overexpression of CrmA, prevents many morphological features of apoptosis but not loss of mitochondrial membrane potential (DCm), phospatidilserine exposure, and cell death. Z-VDVAD-FMK (2 μM) greatly inhibits the Rho-kinase activity in HMEC-1 cells stimulated by Thrombin and displays no effect on control cells. Z-VDVAD-FMK (zVDVAD-fmk) produces a reduction in Lovastatin-induced apoptosis. Z-VDVAD-FMK (100 μM) significantly reduces Lovastatin-induced loss of DNA by 19.1±8.3%. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: The human T-cell leukemia Jurkat (Clone E6.1, ATCC TIB-152) Concentration: 100 μM Incubation Time: 22 hours Result: Prevented Doxorubicin (1 μM)-induced nuclear apoptosis, but not cell death. Form:Solid IC50& Target:Caspase-2
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Z-VDVAD-FMK
CAS number：210344-92-6 molecular formula：C32H46FN5O11
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| Chinese alias | 锌锌合金 | ||
| English alias | Cbz-DL-Val-DL-Asp(OMe)-DL-Val-DL-Ala-DL-Asp(OMe)-CH2F | PD118671 | DTXSID20657590 | Methyl 17-(fluoroacetyl)-8-(2-methoxy-2-oxoethyl)-14-methyl-3,6,9,12,15-pentaoxo-1-phenyl-5,11-di(propan-2-yl)-2-oxa-4,7,10,13,16-pentaazanonadecan-19-oate (non-preferred | ||
| CAS number | 210344-92-6 | molecular formula | C32H46FN5O11 |
| molecular weight | 695.73 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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