Saikogenin D is isolated from Bupleurum chinense , has anti-inflammatory effects. Saikogenin D activates epoxygenases that converts arachidonic acid to epoxyeicosanoids and dihydroxyeicosatrienoic acids, and the metabolites secondarily inhibit prostaglandin E2 (PGE2) production. Saikogenin D results in an elevation of [Ca 2+ ]i due to Ca 2+ release from intracellular stores. In Vitro Saikogenin D (1-20 μM) inhibits PGE2 production induced by the Ca 2+ ionophore A23187 in a concentration-dependent manner with an IC 50 value of 3 μM in C6 rat glioma cells. Saikogenin D (10-100 μM) elevates [Ca 2+ ]i in a concentration-dependent manner with a EC 50 value of 35 μM in the presence or absence of extracellular Ca2+ in C6 rat glioma cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
Saikogenin D
CAS number：5573-16-0 molecular formula：C30H48O4
overview
compound introduction
Specs
| Chinese alias | 柴胡皂苷D | ||
| English alias | - | ||
| CAS number | 5573-16-0 | molecular formula | C30H48O4 |
| molecular weight | 472.7 g/mol | Exact mass | ≥98% |
| PSA | 80.900 Ų | logp | 5.8 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
