SB-408124 Hydrochloride is a selective non-peptide orexin receptor 1 (OX1) receptor antagonist with K i s of 57 nM and 27 nM in whole cell and membrane, respectively. SB-408124 Hydrochloride exhibits 50-fold selectivity over OX2 receptor In Vitro Primary neuronal cultures from the hypothalamus of newborn SD rats are incubated with orexin A (1 µM), orexin A (1 µM) together with SB-408124 (100 µM) for 6 h. Orexin A-induced increases in arginine Vasotocin (AVP) mRNA levels (2.7-fold) are attenuated by SB-408124 (1.2-fold). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo SB-408124 reduces anxiety after psychotraumatic exposure. Predator induces acute psychotraumatic exposure decrease corticoliberin level in the rat's amygdala. Intranasal administration of SB-408124 restores it closely to normal and has an anxiolytic effect on animal behaviour. Bilateral paraventricular nucleus microinjection of SB-408124 (30 pmol/50 nL per side) results in a greater reduction in mean arterial pressure (MAP) in high-salt intake (-16 mmHg) compared with NS-fed (-4 mmHg) anesthetized Dahl salt-sensitive rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:OX 1 Receptor 57 nM (Ki, in whole cell ) OX 1 Receptor 27 nM (Ki, in cell membrane)
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
SB-408124 Hydrochloride
CAS number：1431697-90-3 molecular formula：C19H19ClF2N4O
overview
compound introduction
Specs
| Chinese alias | SB-408124 盐酸盐 | ||
| English alias | N-(6,8-Difluoro-2-methyl-4-quinolinyl)-N'-[4-(dimethylamino)phenyl]urea hydrochloride | F84881 | MS-26581 | SB-408124 HCl | SB-408124 Hydrochloride | AKOS030526528 | SB-408124 (Hydrochloride) | 1-(6,8-difluoro-2-methylquinolin-4-yl)-3-[4-(dimethylamino)ph | ||
| CAS number | 1431697-90-3 | molecular formula | C19H19ClF2N4O |
| molecular weight | 392.83 g/mol | Exact mass | ≥98% |
| PSA | 57.300 Ų | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
