Enpp-1-IN-12 (compound 43) is a potent and orally active ecto-nucleotide pyrophosphatase/phosphodiesterases 1 (ENPP1) inhibitor, with a Ki of 41 nM. Enpp-1-IN-12 exhibits anti-tumor activity In Vitro Enpp-1-IN-12 (5 μM) exhibits half-life and intrinsic clearance of >120 min and In Vivo Enpp-1-IN-12 (100 mg/kg; p.o.) inhibits tumor growth in LLC1 syngeneic murine tumor model for lung cancer . Enpp-1-IN-12 (10 mg/kg; p.o.) exhibits moderate oral bioavailability (F=45.1%), half-life (t 1/2 =1.04 h), and C max (303.10 ng/mL) in healthy female BALB/c mice . Enpp-1-IN-12 (1 mg/kg; i.v.) exhibits half-life (t 1/2 =0.76 h), C max (308.64 ng/mL), and CL of 73.22 mL/min/kg in healthy female BALB/c mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:Ki: 41 nM (ENPP1)
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Enpp-1-IN-12
CAS number：2631703-41-6(DMSO) molecular formula：C16H18N6O3S
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2631703-41-6(DMSO) | molecular formula | C16H18N6O3S |
| molecular weight | 374.42 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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