D-JNKI-1 (AM-111) is a highly potent and cell-permeable peptide inhibitor of JNK . In Vitro D-JNKI-1 (AM-111; 1 μM-1 mM) treatment prevents apoptosis and loss of neomycin-exposed hair cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo D-JNKI-1 (AM-111; 10 μM) prevents nearly all hair cell death and permanent hearing loss induced by neomycin ototoxicity in the scala tympani of the guinea pig cochlea. Local delivery of D-JNKI-1 also prevents acoustic trauma-induced permanent hearing loss in a dose-dependent manner . D-JNKI-1 (0.3 mg/kg, i.p.) reverses these pathological events in the brain mitochondria of the rat and almost completely abolishes cytochrome c release and PARP cleavage. D-JNKI-1 (1 μg/kg, s.c.) results in a significant decrease in the disease activity index, and reduces the expression of CD4 + and CD8 + cells in mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:JNK
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D-JNKI-1
CAS number：1445179-97-4 molecular formula：C164H286N66O40
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| Chinese alias | - | ||
| English alias | BRIMAPITIDE [WHO-DD] | AM-111;XG-102 | F85334 | BRIMAPITIDE [INN] | 2K30142185 | brimapitide | DB15231 | XG-102 | 1445179-97-4 | D-Asp-D-gln-D-ser-D-arg-D-pro-D-val-D-gln-D-pro-D-phe-D-leu-D-asn-D-leu-D-thr-D-thr-D-pro-D-arg-D-lys-D-pro-D-arg-D-pro-D-pro- | ||
| CAS number | 1445179-97-4 | molecular formula | C164H286N66O40 |
| molecular weight | 3822.4 g/mol | Exact mass | ≥99% |
| PSA | - | logp | -20.9 |
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