Nav1.7-IN-3 is a selective, orally bioavailable voltage-gated sodium channel Nav1.7 inhibitor with an IC 50 of 8 nM. Pain relief. Limited CNS penetration In Vivo Nav1.7-IN-3 (compound 5) shows excellent potency, selectivity, behavioral efficacy in a rodent pain model (30 mg/kg, oral, 35 minutes), and efficacy in a mouse itch model (30 mg/kg, oral, 30 minutes) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57BL/6 male mice (n=8/group, 25-30g) Dosage: 1, 3, and 10 mg/kg Administration: Oral (0-35 mintues) Result: Nav1.7-IN-3 demonstrates statistically significant, dose-dependent reversal of these effects in the acute phase of the experiment (0-5 min period post formalin injection) and the tonic phase of the experiment (20-35 min period post formalin injection) with full reversal of formalin effects in the tonic phase Form:Solid IC50& Target:IC50: 8 nM (Nav1.7)
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Nav1.7-IN-3
CAS number：1788872-06-9 molecular formula：C17H20ClFN4O2S2
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 1788872-06-9 | molecular formula | C17H20ClFN4O2S2 |
| molecular weight | 430.95 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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