AER-271 是一种 AER-270 的膦酸酯前药，是aquaporin-4抑制剂，有用于急性缺血性中风的研究潜力。 AER-271, a phosphonate proagent derivative of AER-270, is an aquaporin-4 ( AQP4 ) inhibitor for the research of acute ischemic stroke In Vivo AER-271 is converted in vivo to AER-270 by endogenous phosphatases. AER-271 blocks acute cerebral edema and improves early outcome in a pediatric model of asphyxial cardiac arrest . AER-271 reduces cerebral edema and improves neurological outcomes in rodent ischemic stroke models. Mice treated with AER-271 (5 mg/kg; i.p. injection) show improved outcomes and reduced cerebral edema in a model of ischemic stroke. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male mice (C57BL/6J, 8-12 week-old, 25-30 g)Dosage: 5 mg/kg Administration: Treated by i.p. injection Result: Had better outcomes with an average neurological score of 0.89±0.31 compared with control mice receiving vehicle had an average neurological score of 2.50±0.62. IC50& Target:Aquaporin-4 (AQP4)
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AER-271
CAS number：634913-39-6(DMSO) molecular formula：C15H9ClF6NO5P
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 634913-39-6(DMSO) | molecular formula | C15H9ClF6NO5P |
| molecular weight | 463.65 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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