USP7-IN-7 (compound 124) is a USP7 inhibitor with an IC 50 value ＜10 nM. USP7-IN-7 shows cytotoxicity against p53-mutant cancer cell lines, p53 wild-type blood cancer and neuroblastoma cell lines with low nanomolar values. USP7-IN-7 can be used for cancer research. In Vitro USP7-IN-7 (0-1 μM) shows cytotoxicity against p53 wild-type blood cancer cell lines with CC 50 values of 0.2, 0.2, 0.4 and 0.1 μM for M07e, OCI-AML5, MOLM13 and MM.IS, respectively. USP7-IN-7 (0-2 μM) shows cytotoxicity against p53 wild-type neuroblastoma cell lines with CC 50 values of 1.9, 0.6 and 0.5 μM for SH-SY5Y, CHP-134 and NB-1, respectively. USP7-IN-7 (0-25 μM) shows cytotoxicity against p53-mutant cancer cell lines with CC 50 values of 0.5, 0.2 and 0.2 μM for H526, LA-N-2 and SK-N-DZ, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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USP7-IN-7
CAS number：2413944-70-2 molecular formula：C27H28ClN3O3S
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2413944-70-2 | molecular formula | C27H28ClN3O3S |
| molecular weight | 510.05 g/mol | Exact mass | - |
| PSA | - | logp | - |
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