AGI-24512 is a potent methionine adenosyltransferase 2α ( MAT2A ) inhibitor, with an IC 50 of 8 nM. AGI-24512 triggers DNA damage response. AGI-24512 can block proliferation of MTAP-deleted cancer cells in vitro . AGI-24512 can be used for researching anticancer In Vitro AGI-24512 (0-1 μM; 96 hours) blocks proliferation of MTAP (methylthioadenosine phosphorylase)-deleted HCT116 cancer cells with an IC 50 of 100 nM. AGI-24512 significantly increases in γH2AX-positive cells in MTAP -/- HCT116 cells. AGI-24512 inhibits PRMT5-mediated SDMA marks with an IC 50 of 95 nM in MTAP -/- cells. AGI-24512 leads to a dose-dependent decrease in SAM (S-adenosylmethionine) levels in the HCT116 MTAP- cell, with an IC 50 of 100 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo AGI-24512 shows poor oral absorption and a short half-life in rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 8 nM (MAT2A)
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AGI-24512
CAS number：2201066-53-5(DMSO) molecular formula：C24H24N4O2
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2201066-53-5(DMSO) | molecular formula | C24H24N4O2 |
| molecular weight | 400.47 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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