OP-1074 is a pure antiestrogen and a selective ER degrader (PA-SERD) , shows specific antiestrogenic activity for ERα and ERβ , inhibits 17β-estradiol (E2)-stimulated transcriptional activity with IC 50 of 1.6 and 3.2 nM, respectively In Vitro OP-1074 (0-100 nM; 24 hours) inhibits MCF-7 cells and CAMA-1 cells proliferation with IC50 values of 6.3 and 9.2 nM, respectively. OP-1074 (100 nM; 24 hours) destabilizatizes ERα protein expression in MCF-7 and CAMA-1 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: MCF-7 cells, CAMA-1 cells Concentration: 0 nM, 10 nM,100 nM Incubation Time: 24 hours Result: Inhibited breast cancer cell proliferation. Western Blot AnalysisCell Line: MCF-7 cells, CAMA-1 cells Concentration: 100 nM Incubation Time: 24 hours Result: Downregulated ERα protein expression. Form:Solid IC50& Target:ERα ERβ
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OP-1074
CAS number：1443752-76-8 molecular formula：C29H31NO4
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 1443752-76-8 | molecular formula | C29H31NO4 |
| molecular weight | 457.56 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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