compound introduction
Obtusifoliol is a specific CYP51 inhibitor, Obtusifoliol shows the affinity with K d values of 1.2 µM and 1.4 µM for Trypanosoma brucei (TB) and human CYP51 , respectively In Vitro Obtusifoliol (0.1-100 µM; 48 hours) inhibit MCF-7 and MDA-MB231 breast cancer cells proliferation via arresting cell cycle progression and induction of apoptosis. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: MCF-7; MDA-MB231 breast cancer cells Concentration: 0.1, 1, 10, 40, 80, and 100 µM Incubation Time: 48 hours Result: Inhibited MCF-7 and MDA-MB231 breast cancer cells proliferation. Form:Solid IC50& Target:CYP51 Trypanosoma
