Vorapaxar sulfate (SCH 530348 sulfate), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist ( K i =8.1 nM). Vorapaxar sulfate inhibits thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner In Vitro Vorapaxar sulfate (SCH 530348 sulfate) shows potent inhibition of thrombin-induced platelet aggregation with an IC 50 of 47 nM and haTRAP-induced platelet aggregation with an IC 50 of 25 nM. Vorapaxar sulfate (SCH 530348 sulfate) inhibits thrombininduced calcium transient in human coronary artery smooth muscle cells (HCASMC) with a K i of 1.1 nM. It also inhibits thrombin-stimulated thymidine incorporation in HCASMC with a Ki of 13 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:PAR1
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Vorapaxar sulfate
CAS number：705260-08-8 molecular formula：C29H35FN2O8S
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| Chinese alias | 硫酸沃拉帕沙 | ||
| English alias | DTXSID60990731 | Zontivity | 2-((E)-2-((3R,3aS,4S,4aR,7R,8aR,9aR)-7-((ethoxycarbonyl)amino)-3-methyl-1-oxododecahydronaphtho(2,3-c)furan-4-yl)ethenyl)-5-(3-fluorophenyl)pyridinium hydrogen sulfate | ethyl ((1R,3aR,4aR,6R,8aR,9S,9aS)-9-((E)-2-(5-(3-fluorop | ||
| CAS number | 705260-08-8 | molecular formula | C29H35FN2O8S |
| molecular weight | 590.66 g/mol | Exact mass | ≥99% |
| PSA | 161.000 Ų | logp | - |
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