BAZ1A-IN-1 is a potent inhibitor of BAZ1A (bromodomain-containing protein). BAZ1A-IN-1 shows a K D value of 0.52 μM against BAZ1A bromodomain. BAZ1A-IN-1 shows good anti-viability activity against cancer cell lines expressing a high level of BAZ1A , but weak or no activity against cancer cells with a low expression level of BAZ1A In Vitro BAZ1A-IN-1 (Cpd-2) (0.015-100 ?μM; 96 hours) exhibits good anti-viability activity against all the four cancer cell lines that have a high expression level of BAZ1A, with IC 50 values of 5.08 μM, 4.29 μM, 10.65 μM, and 7.70 μM for THP-1, ZR-75-30, BT474, and H1975 cells, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: THP-10 (leukemia), ZR-75-30 (breast cancer), BT474 (breast cancer), H1975 (lung cancer) cells Concentration: 0.015-100 μM Incubation Time: 96 hours Result: Significantly inhibited the viability activity in four cancer cell lines which all expressed high levels of BAZ1A. IC50& Target:BAZ1A
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BAZ1A-IN-1
CAS number：941521-45-5(DMSO) molecular formula：C16H12N4O3S
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 941521-45-5(DMSO) | molecular formula | C16H12N4O3S |
| molecular weight | 340.36 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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