Cephaeline dihydrochloride is a selective CYP2D6 inhibtor with an IC 50 of 121 μM. In Vitro CYP2D6 reveals the highest metabolic activity for the generation of 9-O-demethylEmetine, whereas this enzyme also shows a significant metabolic activity for the generation of Cephaeline. The IC 50 s of Cephaeline against CYP2C9, CYP2D6 and CYP3A4 is over 1000, 121 and 1000 μM, respectively. Further experiments are performed to determine inhibition constants (K i ) for Cephaeline on the CYP2D6 and CYP3A4 activities Graphic analysis of Dixon plots at various Cephaeline concentrations for each of the two CYP enzyme assays yield K i s of 54 and 355 μM for CYP2D6 and CYP3A4, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 121 μM (CYP2D6), Ki: 54 μM (CYP2D6)
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Cephaeline dihydrochloride
CAS number：5853-29-2 molecular formula：C28H40Cl2N2O4
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| Chinese alias | 盐酸头孢克林 | ||
| English alias | AKOS037514579 | EINECS 227-463-3 | (-)-Cephaeline (dihydrochloride) | Cephaelin Dihydrochloride | (1R)-1-[[(2S,3R,11bS)-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl]methyl]-7-methoxy-1,2,3,4-tetrahydroisoquinolin-6-ol;chloride | ||
| CAS number | 5853-29-2 | molecular formula | C28H40Cl2N2O4 |
| molecular weight | 539.53 g/mol | Exact mass | ≥99% |
| PSA | 63.200 Ų | logp | - |
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