MS645 is a bivalent BET bromodomains (BrD) inhibitor with a K i of 18.4 nM for BRD4-BD1/BD2. MS645 spatially constrains bivalent inhibition of BRD4 BrDs resulting in a sustained repression of BRD4 transcriptional activity in solid-tumor cells In Vitro MS645 has cell growth inhibitory effects on noncancer cell lines of mouse macrophage RAW cells and nontumorigenic breast epithelial MCF10A with IC 50 s of 4.1 nM, 6.8 nM, 7.9 nM for triple-negative breast cancer (TNBC) cell lines HS5878T, BT549, and MCF 10A. ? MS645 (15, 30, 60 nM) results in a dramatic reduction of c-Myc expression and an increase of p21, a tumor suppressor and cell-cycle inhibitor in HCC1806 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:BRD4(BD1BD2) 18.4 nM (Ki)
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MS645
CAS number：2250091-96-2(DMSO) molecular formula：C48H54Cl2N10O2S2
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2250091-96-2(DMSO) | molecular formula | C48H54Cl2N10O2S2 |
| molecular weight | 938.04 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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