RO 4938581 is a potent and selective GABA A α5 inverse agonist, with a K i of 4.6 nM for GABA A α5β3γ2a , and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a ( K i , 174, 185, 80 nM, respectively); RO 4938581 is used in the research of cognitive dysfunction. In Vitro RO 4938581 is a potent and selective GABA A α5 inverse agonist, with a K i of 4.6 nM for GABA A α5β3γ2a, and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a (K i , 174, 185, 80 nM, respectively). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo RO 4938581 (0.3-1 mg/kg, p.o.) reverses a working memory impairment induced by scopolamine the delayed match to position (DMTP) task and a spatial learning impairment induced by diazepam (RO 4938581; 1-10 mg/kg, po) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Ki: 4.6 nM (GABA A α5β3γ2a), 174 nM (GABA A α1β3γ2a), 185 nM (GABA A α2β3γ2a), 80 nM (GABA A α3β3γ2a)
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RO 4938581
CAS number：883093-10-5 molecular formula：C13H8BrF2N5
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| Chinese alias | 罗马尼亚 4938581 | ||
| English alias | - | ||
| CAS number | 883093-10-5 | molecular formula | C13H8BrF2N5 |
| molecular weight | 352.14 g/mol | Exact mass | ≥99% |
| PSA | 48.500 Ų | logp | 2.5 |
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