OXFBD04 is a potent and selective BRD4 inhibitor with an IC 50 of 166 nM. OXFBD04 is a potent BET bromodomain ligand with additional modest affinity for the CREBBP bromodomain. OXFBD04 has anti-cancer activity In Vitro OXFBD04 (0.01-100 μM; 48 hours) inhibits cancer cell lines growth. OXFBD04 (10 µM; for 10, 24, or 48 hours) induces MYC suppression in MCF7 breast cancer cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: A498 (renal), HT-29 (colon), and MCF7 (breast) cancer cell lines Concentration: 0.01, 0.1, 1, 10, 100 μM Incubation Time: 48 hours Result: Inhibited cancer cell lines growth. In Vivo OXFBD04 has optimised physicochemical properties (LE=0.43; LLE=5.74; SFI=5.96), and good metabolic stability (t 1/2 =388 min). OXFBD04 has CL int of 3.57 µL/min/mg . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:BRD4 166 nM (IC 50 )
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OXFBD04
CAS number：2231747-03-6(DMSO) molecular formula：C17H16N2O3
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2231747-03-6(DMSO) | molecular formula | C17H16N2O3 |
| molecular weight | 296.32 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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