CXCR2-IN-1 is a central nervous system penetrant CXCR2 antagonist with a pIC 50 of 9.3. In Vitro CXCR2 plays an important role in the activation and recruitment of neutrophils to sites of inflammation. CXCR2-IN-1 (compound 22) shows favorable central nervous system penetration property (Br/Bl>0.45). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo CXCR2-IN-1 shows efficacy in a cuprizone-induced demyelination model through oral administration, providing evidence to support CXCR2 to be a potential therapeutic target to treat demyelinating diseases such as multiple sclerosis . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:CXCR2 9.3 (pIC 50 )
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CXCR2-IN-1
CAS number：1873376-49-8 molecular formula：C19H20Cl2FN3O4S
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 1873376-49-8 | molecular formula | C19H20Cl2FN3O4S |
| molecular weight | 476.35 g/mol | Exact mass | ≥99% |
| PSA | 107.000 Ų | logp | 3.900 |
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