CAS number：1226443-41-9(DMSO) molecular formula：C15H15N5OS2
HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation. HQ461-mediated degradation of cyclin K impairs CDK12 function, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death.
| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 1226443-41-9(DMSO) | molecular formula | C15H15N5OS2 |
| molecular weight | 345.44 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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