compound introduction
PROTAC BET Degrader-1 is a PROTAC connected by ligands for Cereblon and BET , decreasing BRD2 , BRD3 , and BRD4 protein levels at low concentration. In Vitro PROTAC BET Degrader-1 (Compound 9) is a potent BET degrader based on PROTAC, decreases the level of BRD2, BRD3, and BRD4 proteins in RS4;11 cells at 3-10 nM, and inhibits the growth of this cell line with an IC 50 of 4.3 nM, and 45.5 nM for MOLM-13 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:BET
