PROTAC BRD4 Degrader-8 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4 , with IC 50 s of 1.1 nM and 1.4 nM for BRD4 BD1 and BD2 , respectively. PROTAC BRD4 Degrader-8 is capable of potently degrading the BRD4 protein in PC3 prostate cancer Appearance:Solid IC50& Target:IC50: 1.1 nM (BRD4 BD1), 1.4 nM (BRD4 BD2) In Vitro:PROTAC BRD4 Degrader-8 (compound 8; 6 days) inhibits the proliferation of PC3 prostate cancer cells, with an IC 50 of 28 nM. PROTAC BRD4 Degrader-8 (4 h) suppresses MYC gene transcript in MV4-11 AML cells, with an IC 50 of 11 nM. PROTAC BRD4 Deg Biological Activity:PROTAC BRD4 Degrader-8 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4 , with IC 50 s of 1.1 nM and 1.4 nM for BRD4 BD1 and BD2 , respectively. PROTAC BRD4 Degrader-8 is capable of potently degrading the BRD4 protein in PC3 prostate cancer
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PROTAC BRD4 Degrader-8
CAS number：unknown molecular formula：C53H61F2N9O11S2
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| Chinese alias | PROTAC BRD4 降解剂-8 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C53H61F2N9O11S2 |
| molecular weight | 1102.23 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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