PD 90780 是神经生长因子 (NGF) 的非肽拮抗剂。PD 90780 与 NGF 相互作用阻止与 p75NTR 结合。PD 90780 抑制 NGF-p75NTR 相互作用,在 PC12 和 PC12nnr5 细胞中的 IC50 值分别为 23.1 和 1.8 µM。
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PD 90780
CAS number:77422-99-2 molecular formula:C19H14N4O4
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compound introduction
Specs
| Chinese alias | 7-(苯甲酰基氨基)-4,9-二氢-4-甲基-9-氧代吡唑并[5,1-b]喹唑啉-2-羧酸 | ||
| English alias | 7-(Benzoylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid | ||
| CAS number | 77422-99-2 | molecular formula | C19H14N4O4 |
| molecular weight | 362.34 g/mol | Exact mass | ≥98%(HPLC) |
| PSA | 105.000 Ų | logp | 2.600 |
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