CAS number：2109805-96-9 molecular formula：C15H20N4O2
BAY-707 是 MTH1(NUDT1) 的底物竞争性，高效选择性抑制剂，IC50 值 为 2.3 nM。 BAY-707 与其他 MTH1 化合物相比具有良好的药代动力学特征，并且在小鼠中具有良好的耐受性，但实验明显缺乏体外或体内抗癌功效。 BAY-707 is a substrate-competitive, highly potent and selective inhibitor of MTH1(NUDT1) with an IC50 of 2.3 nM. BAY-707 has a good pharmacokinetic (PK) profile to other MTH1 compounds and is well-tolerated in mice, but shows a clear lack of in vitro or in vivo anticancer efficacy。
| Chinese alias | N-乙基-4-[(3S)-3-甲基-4-吗啉基] -1H-吡咯并[2,3-b]吡啶-2-甲酰胺 | ||
| English alias | N-Ethyl-4-[(3S)-3-methyl-4-morpholinyl]-1H-pyrrolo[2,3-b]pyridine-2-carboxamide | (S)-N-Ethyl-4-(3-methylmorpholino)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide | ||
| CAS number | 2109805-96-9 | molecular formula | C15H20N4O2 |
| molecular weight | 288.34 g/mol | Exact mass | ≥98%(HPLC) |
| PSA | - | logp | - |
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