MSC-1186 is a highly selective pan-SRPK inhibitor. MSC-1186 has activity for SRPK1, SRPK2 and SRPK3 with IC 50 values of 2.7 nM, 81 nM and 0.6 nM, respectively. MSC-1186 can be used for the research of cancer In Vitro MSC-1186 has activity for SRPK1 and SRPK3 in HEK293T cells with EC 50 values of 98 nM and 40 nM, respectively. MSC-1186 has activity for SRPK1, SRPK2 and SRPK3 with IC 50 values of 2.7 nM, 81 nM and 0.6 nM, respectively. MSC-1186 has excellent kinome-wide selectivity. MSC-1186 shows additive attenuation of SR-protein phosphorylation when is used in combination with CDC2-like kinase (CLK) inhibitors. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 2.7 nM (SRPK1), 81 nM (SRPK2), 0.6 nM (SRPK3),EC50 in HEK293T cells: 98 nM (SRPK1), 40 nM (SRPK3)
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MSC-1186
CAS number：2871698-23-4 molecular formula：C19H17ClFN7O2S
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2871698-23-4 | molecular formula | C19H17ClFN7O2S |
| molecular weight | 461.90 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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