IMD-0560 is a novel IκB kinase β inhibitor. In Vitro Pretreatment with IMD-0560 inhibits both IκBα degradation and p65 phosphorylation induced by TNFα. IMD-0560 also suppresses TNFα-induced transcriptional activity. Pretreatment with IMD-0560 strongly inhibits TNFα-induced cell invasion. Pretreatment with IMD-0560 suppresses MMP-9 activity by inhibiting MMP-9 expression. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo The tumor size is reduced in the IMD-0560-treated groups in a dose-dependent manner, and no tumor is detected in some mice treated with 5 mg/kg IMD-0560. Zygoma destruction is significantly suppressed in the IMD-0560-treated groups compare to the control groups. Although the tumor size in the 5 mg/kg IMD-0560-treated group is smaller than that of the 3 mg/kg IMD-0560-treated group, the inhibitory effect of each treatment on zygoma destruction is similar . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IKKβ
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IMD-0560
CAS number：439144-66-8 molecular formula：C15H8BrF6NO2
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| Chinese alias | - | ||
| English alias | n-(2,5-bis(trifluoromethyl)phenyl)-5-bromo-2-hydroxybenzamide | Q27258424 | 419X829330 | MS-27565 | 5-Bromo-2-hydroxy-N-[2,5-bis(trifluoromethyl)phenyl]benzamide | SCHEMBL331595 | AKOS040741873 | Benzamide, N-(2,5-bis(trifluoromethyl)phenyl)-5-bromo-2-hyd | ||
| CAS number | 439144-66-8 | molecular formula | C15H8BrF6NO2 |
| molecular weight | 428.12 g/mol | Exact mass | ≥99% |
| PSA | 49.300 Ų | logp | 5.400 |
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