Hydrocortisone cypionate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. In Vitro Hydrocortisone (50 nM) shows a dose-dependent down-regulation of GR transcript in hCMEC/D3 cells. Hydrocortisone supplementation of the serum-reduced cell differentiation medium leads to a significant increase in TER across the hCMEC/D3 monolayer. Hydrocortisone-treated Dendritic cells (DCs) show a decreased expression of MHC II molecules, the costimulatory molecule CD86, and the DC-specific marker CD83, as well as a strongly reduced IL-12 secretion. Hydrocortisone-treated DCs inhibit production of IFN-γ but induce an increased release of IL-4 and no change in IL-5. Hydrocortisone reduces postischemic oxidative stress, perfusion pressure, and transudate formation. Hydrocortisone inhibits postischemic shedding of syndecan-1, heparan sulfate, and hyaluronan as is release of histamine from resident mast cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
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Hydrocortisone cypionate
CAS number：508-99-6 molecular formula：C29H42O6
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| Chinese alias | 氢化可的松环戊丙酸酯 | ||
| English alias | HYDROCORTISONE CYPIONATE | 2-[(1R,3aS,3bS,9aR,9bS,10S,11aS)-1,10-dihydroxy-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl]-2-oxoethyl 3-cyclopentylpropanoate | CHEMBL1549 | Hydrocortisone 21.beta.- | ||
| CAS number | 508-99-6 | molecular formula | C29H42O6 |
| molecular weight | 486.64 g/mol | Exact mass | - |
| PSA | 101.000 Ų | logp | 4.7 |
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