Fosifloxuridine nafalbenamide (NUC-3373), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor. Fosifloxuridine nafalbenamide has anticancer activity. Fosifloxuridine nafalbenamide has the potential to evoke a host immune response and enhance immunoresearch. In Vitro Fosifloxuridine nafalbenamide induces the release of damage-associated molecular patterns (DAMPs), with increased expression of calreticulin (CRT) at the cell surface and concomitant loss of nuclear nuclear high mobility group box protein 1 (HMGB1). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Fosifloxuridine nafalbenamide exhibits anti-cancer activity in HT-29 nude mouse xenograft models. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
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Fosifloxuridine nafalbenamide
CAS number：1332837-31-6 molecular formula：C29H29FN3O9P
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| Chinese alias | 磷尿苷那法苯胺 | ||
| English alias | N-(2'-Deoxy-5-fluoro-P-1-naphthalenyl-5'-uridylyl)-L-alanine phenylmethyl ester | 1332837-31-6 | NUC-3373 | CPF-373 | FOSIFLOXURIDINE NAFALBENAMIDE [INN] | benzyl (2S)-2-[[[(2R,3S,5R)-5-(5-fluoro-2,4-dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy-napht | ||
| CAS number | 1332837-31-6 | molecular formula | C29H29FN3O9P |
| molecular weight | 613.53 g/mol | Exact mass | - |
| PSA | 153.000 Ų | logp | 3.000 |
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