GNE-131 是有效的人类钠离子通道 NaV1.7(hNaV1.7)选择性抑制剂，IC50为 3 nM GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7 , with an IC 50 of 3 nM. In Vitro GNE-131 (Compound 13) shows moderate clearance in human liver microsomes and excellent functional activity against human NaV1.7 with an IC 50 of 0.003±0.001 μM. GNE-131 shows excellent potency, good in vitro metabolic stability. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo GNE-131 shows low in vivo clearance in mouse, rat, and dog. GNE-131 also displays excellent efficacy in a transgenic mouse model of induced pain . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:Na v 1.7 3 nM (IC 50 )
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GNE-131
CAS number：1629063-81-5(DMSO) molecular formula：C23H30N4O3S
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 1629063-81-5(DMSO) | molecular formula | C23H30N4O3S |
| molecular weight | 442.57 g/mol | Exact mass | - |
| PSA | - | logp | - |
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