CCT251455 is a potent and selective mitotic kinase monopolar spindle 1 ( MPS1 ) inhibitor with an IC 50 of 3 nM. In Vitro CCT251455 is a highly potent inhibitor of MPS1 that demonstrates high selectivity versus kinases tested in a broad kinome profiling panel. CCT251455 inhibits P-MPS1 with an IC 50 of 0.04 μM in cell-based assay and has a GI 50 of 0.16 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo CCT251455 demonstrates a good oral pharmacokinetic profile in mouse and rat as well as inhibition of MPS1 activity in vivo following oral administration . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 3 nM (MPS1)
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CCT251455
CAS number：1400284-80-1 molecular formula：C26H26ClN7O2
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 1400284-80-1 | molecular formula | C26H26ClN7O2 |
| molecular weight | 503.98 g/mol | Exact mass | ≥98% |
| PSA | 91.800 Ų | logp | 4.400 |
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