KB-5492 free base is a potent and selective inhibitor of sigma receptor , inhibits specific [ 3 H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor with an IC 50 of 3.15 μM. KB-5492 free base is an anti-ulcer agent In Vitro KB-5492 (0.001-100 μM) free base inhibits specific [ 3 H]DTG binding in a concentration-dependent manner. KB-5492 (0.1-1 mM) free base significantly and concentration-dependently prevents the ethanol- and acidified aspirin-induced increases in 51 Cr release from gastric epithelial cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo KB-5492 (200 mg/kg; p.o.) free base prevents macroscopic lesions in the gastric mucosa. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Sprague-Dawley rats weighing 210-240 g are induced gastric mucosal damageDosage: 200 mg/kg Administration: Oral gavage Result: Reduced the lesion length as compared with the control. Prevented the deep mucosal lesions and exfoliation of surface epithelial cells. Form:Solid IC50& Target:IC50: 3.15 μM (sigma receptor)
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KB-5492 free base
CAS number：113594-64-2 molecular formula：C23H30N2O6
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| Chinese alias | KB-5492 游离碱 | ||
| English alias | - | ||
| CAS number | 113594-64-2 | molecular formula | C23H30N2O6 |
| molecular weight | 430.49 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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