Namitecan is a potent topoisomerase I inhibitor, with antitumor property. In Vitro Namitecan and cetuximab cooperate in inhibiting EGFR expression. Namitecan induces a dose-dependent decrease in EGFR expression in the different cell lines. ST1968 induces a comparable level of apoptosis in A431 and A431/TPT cells with IC 50 of 0.21 and 0.29 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Namitecan (10 mg/kg) in combination with cetuximab (1 mg/mouse) induces synergistic antitumor effects in SCC models as a function of EGFR gene copy number . ST1968 (25 mg/kg) causes acceptable body weight loss and no toxic deaths. ST1968 produces a 100% complete response rate in the mice bearing the A431 tumor, and retains a relevant activity in the topotecan-resistant tumor. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Topoisomerase I
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Namitecan
CAS number：372105-27-6 molecular formula：C23H22N4O5
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| Chinese alias | 纳米替康 | ||
| English alias | MS-27779 | NAMITECAN [WHO-DD] | X34Z8N66T3 | st1968 | ST-1968 | AKOS040742269 | ST 1968 | SCHEMBL24685130 | (S)-4-Ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-11-carbaldehyde O-(2-aminoethyl) oxime | HY-14 | ||
| CAS number | 372105-27-6 | molecular formula | C23H22N4O5 |
| molecular weight | 434.44 g/mol | Exact mass | ≥99% |
| PSA | 127.000 Ų | logp | 0.100 |
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