RBN-3143 is a potent and NAD+-competitive catalytic PARP14 inhibitor with an IC 50 value of 4 nM. RBN-3143 inhibits PARP14-mediated ADP-ribosylation and stabilizes PARP14 in cell lines. RBN-3143 can be used in research of lung inflammation In Vivo RBN-3143 (5 μg; intranasal administration) can improve steroid-resistant asthma mouse models . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Mouse of asthma models Dosage: 5 ug Administration: Intranasal administration Result: Suppressed the accumulation of alarmins TSLP, IL-33, and IL-25. Form:Solid IC50& Target:PARP14 4 nM (IC 50 ) PARP10 1600 nM (IC 50 ) PARP15 4200 nM (IC 50 ) PARP4 42700 nM (IC 50 ) PARP3 >100000 nM (IC 50 ) PARP2 >100000 nM (IC 50 ) PARP1 >100000 nM (IC 50 )
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
RBN-3143
CAS number：2360853-16-1 molecular formula：C22H28FN3O4S
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2360853-16-1 | molecular formula | C22H28FN3O4S |
| molecular weight | 449.54 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
