compound introduction
Dagrocorat (PF-00251802) hydrochloride is an orally active and selective high-affinity partial agonist of the glucocorticoid receptor . Dagrocorat hydrochloride is also a time-dependent reversible inhibitor of CYP3A ( IC 50 =1.3 μM in human liver microsomes) and CYP2D6 ( K i =0.57 μM in human liver microsomes). Dagrocorat hydrochloride can be used for the research of rheumatoid arthritis In Vitro Dagrocorat hydrochloride is metabolized by cytochrome P450 (CYP)3A to an N-oxide metabolite. Dagrocorat hydrochloride is a reversible inhibitor of several CYPs, such as CYP3A and CYP2D6. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:CYP3A CYP2D6
